Granulomatosis with polyangiitis: Possible endocrine manifestations

Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, is a necrotizing vasculitis of small and medium-sized blood vessels characterized by diffuse inflammation vascular structures perivascular extravascular granulomatosis. In its systemic form, GPA predominantly affects the ear, nose throat, lung kidney involvement typically rapidly progressive glomerulonephritis extracapillary crescents, while absence damage at time diagnosis defined limited form more favorable prognosis (1, 2). Antineutrophil cytoplasmic antibodies (c-ANCA) specificity for proteinase 3 (PR3) represent biochemical diagnostic criterion. They are detected in 90% generalized forms about 50% granulomatosis treatment, disease evolution. Systemic corticosteroid therapy immunosuppressive significantly changed prognostic aspect disease. Only few sporadic observations have been published on endocrine disorders associated GPA. We present case man, 39 years old, who developed autoimmune thyroiditis 8 after initial diagnosis.